Objective
The relationship of homocyteine, B12 and folic acid with osteoporosis has already been studied in various populations. We
compared the important factors in the metabolism of homocysteine, such as homocysteine, B12 and folic acid levels, of Turkish
postmenopausal women, and their relationship with the femur and lumbar spine bone mineral density.
Methods
This cross-sectional study was conducted at Gazi University, Department of Obstetrics and Gynecology. The study group consisted
of 178 postmenopausal women. Serum homocysteine, folic acid and Vitamin B12 were measured. BMD was measured using DEXA at
the right femoral neck and lumbar spine (L1–L4).
Results
Upon evaluation of both the femur and lumbar spine, it was determined that osteoporosis could be associated with a homocysteine
level above the median and with a B12 value under the lowest quintile value.
Conclusion
Plasma Hcy and vitamin B12, but not folate levels, were associated with osteoporosis. Future interventional studies are needed
to determine methods to reduce Hcy levels with dietary supplements and extra vitamin B12, which will restore bone health and
reduce risk of fractures.
Keywords Homocysteine - Folic acid - Vitamin B12 - Osteoporosis