Child's Nervous System
Volume 24, Number 7, 855-857, DOI: 10.1007/s00381-007-0578-0Open Access

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Case Report

Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation

A. C. J. Ammerlaan, M. P. W. A. Houben, C. C. Tijssen, P. Wesseling and T. J. M. Hulsebos

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Abstract

Objective  

We report on a patient who developed a meningioma more than two decades after removal at a young age of an atypical teratoid/rhabdoid tumour (AT/RT), which was due to a germline INI1 mutation, and radio- and chemotherapy.

Materials and methods  

We present genetic evidence that the meningioma is not a recurrence or metastasis of the AT/RT and not due to the INI1 mutation, but is a radiation-induced tumour.

Conclusion  

This is the first case illustrating that improved survival of young patients with an AT/RT after aggressive treatment may be gained at the cost of an increased risk for the development of radiation-induced, non-INI1-related tumours.

Keywords  Meningioma - Radiation therapy - Atypical teratoid/rhabdoid tumour - Genetic predisposition -  INI1

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