Recently, hiding secret data in DNA becomes an important and interesting research topic. Some researchers hid data in non-transcribed DNA, non-translated RNA regions, or active coding segments. Unfortunately, these schemes either alter the functionalities or modify the original DNA sequences. As a result, how to embed the secret data into the DNA sequence without altering the functionalities and to have the original DNA sequence be able to be retrieved is worthy of investigating. This paper apply two reversible information hiding schemes on DNA sequence by using the difference expansion technique and lossless compression. The reversible property makes the secret data hidden in anywhere in DNA without altering the functionalities because the original DNA sequence can be recovered in our schemes.