You have Guest access.
Log In
Volume 1 / 1987 - Volume 26 / 2012
Formerly merged with Perspectives in Drug Discovery and Design (1993-2000)
Special Issue: Fragment-Based Drug Design / Guest Edited by D. Joseph-McCarthy
449-451
Guest Editorial
Challenges of fragment screening
Diane Joseph-McCarthy
453-458
Warr's Piece
Fragment-based drug discovery
Wendy A. Warr
459-473
The multiple roles of computational chemistry in fragment-based drug design
Richard Law, Oliver Barker, John J. Barker, Thomas Hesterkamp and Robert Godemann, et al.
475-489
The multi-copy simultaneous search methodology: a fundamental tool for structure-based drug design
Christian R. Schubert and Collin M. Stultz
491-500
Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase
Melissa R. Landon, Raquel L. Lieberman, Quyen Q. Hoang, Shulin Ju and Jose M. M. Caaveiro, et al.
501-511
Fragment-based lead generation: identification of seed fragments by a highly efficient fragment screening technology
Lars Neumann, Allegra Ritscher, Gerhard Müller and Doris Hafenbradl
513-525
Design of compound libraries for fragment screening
Niklas Blomberg, David A. Cosgrove, Peter W. Kenny and Karin Kolmodin
527-539
Virtual fragment screening: an exploration of various docking and scoring protocols for fragments using Glide
Sameer Kawatkar, Hongming Wang, Ryszard Czerminski and Diane Joseph-McCarthy
541-554
Energetic analysis of fragment docking and application to structure-based pharmacophore hypothesis generation
Kathryn Loving, Noeris K. Salam and Woody Sherman
555-569
Development and NMR validation of minimal pharmacophore hypotheses for the generation of fragment libraries enriched in heparanase inhibitors
Rafael Gozalbes, Silvia Mosulén, Rodrigo J. Carbajo and Antonio Pineda-Lucena
571-582
Computational fragment-based drug design to explore the hydrophobic sub-pocket of the mitotic kinesin Eg5 allosteric binding site
Ksenia Oguievetskaia, Laetitia Martin-Chanas, Artem Vorotyntsev, Olivia Doppelt-Azeroual and Xavier Brotel, et al.
583-592
Structural models in the assessment of protein druggability based on HTS data
Anvita Gupta, Arun Kumar Gupta and Kothandaraman Seshadri
593-602
Second-generation de novo design: a view from a medicinal chemist perspective
Andrea Zaliani, Krisztina Boda, Thomas Seidel, Achim Herwig and Christof H. Schwab, et al.
603-620
Lessons for fragment library design: analysis of output from multiple screening campaigns
I-Jen Chen and Roderick E. Hubbard
Frequently asked questions General info on journals and books Send us your feedback Impressum Contact us
© Springer, Part of Springer Science+Business Media Privacy, Disclaimer, Terms & Conditions, and Copyright Info