Calculated in terms of surface runoff plus irrepeated groundwater, there is about 8.67×10¹⁰m³ of total available water resources in the inland river basins of arid Northwest China. Water resources is the decisive factor for survival of oases and human being. But there have arisen several aspects of serious eco-environment problems resulted from irrational exploitation and utilization. From now on, the development and utilization of water not only requires to promote regional economy, but also needs to protect and improve the environment based on their potential. Sustainable utilization needs to broaden new sources and saving water at first. Then three measures are recommended.