An in vivo prospective study compared the effectiveness of 0.3% ciprofloxacin to 0.3% ofloxacin against
Pseudomonas aeruginosa keratitis in rabbits. Ofloxacin-treated corneas yielded an average amount of colony-forming units (CFUs) of
P aeruginosa that was statistically significantly higher than that of ciprofloxacin-treated corneas (4.7×10
4±2.2×10
3 vs 2.5×10
3±1.0×10
2). Thus, ciprofloxacin was more effective than ofloxacin in the early reduction of CFUs in
P aeruginosa keratitis in rabbits.