Amino Acids
Volume 31, Number 4, 427-433, DOI: 10.1007/s00726-006-0321-2

Domino reactions with fluorinated five-membered heterocycles. α-Trifluoromethyl α-amino acids with unsaturated side-chains

K. Burger, L. Hennig, P. Tsouker, J. Spengler, F. Albericio and B. Koksch

From the issue entitled "Special issue: Focus on Postnatal CNS Plasticity"

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Abstract

α-Trifluoromethyl α-amino acids with unsaturated side-chains have been prepared from 5-fluoro-4-trifluoromethyloxazole and allyl, propargyl as well as terpene alcohols in a one-pot procedure.

Keywords: 5-Fluoro-4-trifluoromethyloxazoles – Allyl alcohols – Propargyl alcohols – Geraniol – Farnesol – Nucleophilic aromatic substitution – Claisen rearrangement – α-Trifluoromethyl α-amino acids – Secondary structure

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