307-331
Importance of Within Subject Variation in Levodopa Pharmacokinetics: A 4Year Cohort Study in Parkinson’s Disease
Phylinda L. S. Chan, John G. Nutt and Nicholas H. G. Holford
333-358
Cluster Analysis: An Alternative Method for Covariate Selection in population Pharmacokinetic Modeling
Nabil Semmar, Bernard Bruguerolle, Sandrine Boullu-Ciocca and Nicolas Simon
359-376
Pharmacodynamic Analysis of Changes in Reticulocyte Subtype Distribution in Phlebotomy-Induced Stress Erythropoiesis
Nidal H. Al-Huniti, John A. Widness, Robert L. Schmidt and Peter Veng-Pedersen
377-400
Unified Pharmacogenetics-Based Parent–Metabolite Pharmacokinetic Model Incorporating Acetylation Polymorphism for Talampanel in Humans
Peter Buchwald, Attila Juhász, Cynthia Bell, Márta Pátfalusi and John Howes, et al.
401-418
Propagation of Population Pharmacokinetic Information Using a Bayesian Approach: Comparison with Meta-Analysis
Aristides Dokoumetzidis and Leon Aarons
419-439
Population Pharmacokinetics of the Active Metabolite of Leflunomide in Pediatric Subjects with Polyarticular Course Juvenile Rheumatoid Arthritis
Jun Shi, Steven J. Kovacs, Yaning Wang, Thomas M. Ludden and Vijay O. Bhargava
441-457
Some Considerations on the Design of Population Pharmacokinetic Studies
Stephen Duffull, Tim Waterhouse and John Eccleston
459-484
Pharmacokinetic and Pharmacodynamic Changes During the First Four Years of Levodopa Treatment in Parkinson’s Disease
Phylinda L. S. Chan, John G. Nutt and Nicholas H. G. Holford
485-500
Population Pharmacokinetic–Pharmacodynamic Modeling of Subcutaneous and Pulmonary Insulin in Rats
Mathangi Gopalakrishnan, Sandra Suarez, Anthony J. Hickey and Jogarao VS Gobburu
501-520
Collapsing Mechanistic Models: An Application to Dose Selection for Proof of Concept of a Selective Irreversible Antagonist
Matthew M. Hutmacher, Debu Mukherjee, Kenneth G. Kowalski and David C. Jordan
521-545
Optimal Design for Model Discrimination and Parameter Estimation for Itraconazole Population Pharmacokinetics in Cystic Fibrosis Patients
Timothy H. Waterhouse, Stefanie Redmann, Stephen B. Duffull and John A. Eccleston
547-570
The Acute Disposition of (R)- and (S)-Methadone in Brain and Lung of Sheep
David J. R. Foster, Richard N. Upton, Andrew A. Somogyi, Cliff Grant and Allison Martinez
571-605
The Population Pharmacokinetics of Citalopram After Deliberate
Self-Poisoning: A Bayesian Approach
Lena E. Friberg, Geoffrey K. Isbister, L. Peter Hackett and Stephen B. Duffull
607-654
A Dynamical Systems Analysis of the Indirect Response Model with Special Emphasis on Time to Peak Response
Lambertus A. Peletier, Johan Gabrielsson and Jacintha den Haag