Purpose To evaluate the curative effect of acupuncture on depressive neurosis.Method Sixty-two patients were randomly divided into a treatment group of 32 cases and a control group of 30 cases. The treatment group and the control group were treated with acupuncture and Fluoxetine, respectively. The curative effects were evaluated by HAMD.Results There was a significant difference between pretreatment and posttreatment in each group (P<0.02). There were no significant differences in curative effect and score reduction rate between the two groups (P>0.05). But acupuncture had no side effects and was good in compliance.Conclusion Acupuncture is an effective method for treating depressive neurosis.