Morphological and anatomical features (including wood anatomy and pollen morphology) of the small neotropical genusPagameopsis (Rubiaceae-Rubioideae) are discussed and illustrated. The fused ovaries, fenestrate corolla tube, basally attached anther filaments, and absence of raphides are especially noteworthy.Pagameopsis is definitely not a member of the Psychotrieae because of significant differences in wood anatomy and gynoecial and fruit structure. A close affinity with Gaertnereae seems doubtful for similar reasons. The taxonomic affinities ofPagameopsis remain obscure. The genus shows similarities with several taxa of the Rubioideae, such as Coccocypseleae, Morindeae, Hedyotideae, andMetabolos. The absence of raphides, on the other hand, makes a position in the Rubioideae doubtful.