The European research project INT-MANUS embedded in the I*PROMS European network of excellence addresses the increasing demand for flexibility and adaptivity, which is summarized by rapid reconfigurations of complete factories as well as related aspects in Human Computer Interaction (HCI), Software, and Production Systems. The project’s main goal is to develop a new technology for the production plants of the future, the Smart Connected Control Platform (SCCP). This platform allows controlling a factory with the help of an open distributed learning agent platform that integrates machines, robots, and human personnel.