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Pitavastatin may Reduce Risk of Steroid-induced Osteonecrosis in Rabbits: A Preliminary Histological Study
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Symposium: Molecular and Surgical Advances in Osteonecrosis
Pitavastatin may Reduce Risk of Steroid-induced Osteonecrosis in Rabbits: A Preliminary Histological Study
Kenjiro Nishida1, Takuaki Yamamoto1  , Goro Motomura1, Seiya Jingushi1 and Yukihide Iwamoto1
| (1) |
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan |
Received: 29 May 2007 Accepted: 12 February 2008 Published online: 19 March 2008
Abstract Several animal and human studies suggest pharmacological approaches may prevent steroid-induced osteonecrosis (ON). We asked
whether the newly developed 3-hydroxymethyl-3-glutaryl-CoA (HMG-CoA) reductase inhibitor, pitavastatin, could prevent steroid-induced
ON in rabbits. We injected 65 adult male Japanese white rabbits once with 20 mg/kg of methylprednisolone acetate into the
right gluteus medius muscle. The rabbits were divided into two groups; one group of 35 rabbits received pitavastatins (PS),
and the other group of 30 rabbits received no prophylaxis (CTR). Hematological examinations were performed just before the
steroid injection (0 weeks) and at 1 and 2 weeks after steroid injection; both the femora and the humeri were histologically
examined 2 weeks postinjection. The incidence of histologic changes consistent with early ON in the PS group (13 of 35; 37%)
was lower in comparison to the CTR group (21 of 30; 70%). The size of the bone marrow fat cells in the PS group (56.6 ± 10 μm)
was smaller than those in the CTR group (60 ± 4 μm). The data suggest pitavastatin has the potential to lower the incidence
of steroid-induced ON in rabbits.
One of more of the authors (TY) received funding from a Grant-in-Aid in Scientific Research (No.18591665) from the Japan Society
for the Promotion of Science.
Each author certifies that his or her institution has approved the animal protocol for this investigation and that all investigations
were conducted in conformity with ethical principles of research.
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