1. The effect of endocrine dyscrasia on vitamin absorption, and the resultant interference in the synergistic action of vitamins
and hormones has been demonstrated.
2. Six representative cases, selected from a series of 200, have been discussed in detail.
3. Alleviation of symptoms, and pronounced improvement in general nutritional status was effected by substitution therapy.
4. In cases of the type herein presented, the underlying disorder is almost invariably obscure, but detailed history, careful
analysis, and correlation of all data will provide the clue to diagnosis and frequently reveal the key to proper therapy.
5. Substitution therapy must be administered from the point of view of the entire endocrine picture, and should provide complete
hormone replacement.