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Stevens-Johnson syndrome in children receiving phenobarbital therapy and cranial radiotherapy
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Clinical-Patient Studies
Stevens-Johnson syndrome in children receiving phenobarbital therapy and cranial radiotherapy
Antonio Ruggiero1, Paola Sabrina Buonuomo2  , Palma Maurizi1, Maria Pia Cefalo1, Mirta Corsello1 and Riccardo Riccardi1
| (1) |
Department of Paediatrics, Pediatric Oncology, Università Cattolica del Sacro Cuore, Policlinico “A. Gemelli”, Rome, Italy |
| (2) |
Department of Pediatric Medicine, Ospedale Pediatrico “Bambino Gesù” IRCCS, Rome, Italy |
Received: 13 April 2007 Accepted: 23 April 2007 Published online: 23 June 2007
Abstract Stevens-Johnson syndrome (SJS) is a severe cutaneous eruption that most often appears as an adverse reaction to medication.
In this report, we present two children with brain tumour who developed SJS while receiving cranial irradiation and anticonvulsant
therapy with phenobarbital. Concomitant application of these two therapies may play an important role in the occurrence of
the disease.
Keywords Stevens-Johnson syndrome - Erythema multiforme major - Cranial irradiation - Anticonvulsant therapy
An erratum to this article can be found at
http://dx.doi.org/10.1007/s11060-008-9532-6
 References secured to subscribers.
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