Volume 90, Number 1, 85-88, DOI: 10.1007/s11060-008-9636-z

Prolonged survival after multifocal brain radiation necrosis associated with whole brain radiation for brain metastases: case report

Mirela Cerghet, Bruce Redman, Larry Junck, Jeffrey Forman and Lisa R. Rogers

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Abstract

Radiation necrosis of the brain is a well documented adverse effect of radiation therapy. The authors report an unusual case of relapsing multifocal radiation necrosis following whole brain radiation therapy (WBRT) for brain metastases from a systemic germ cell tumor. Anticoagulation with warfarin may have had therapeutic benefit. The patient is alive without a neurological deficit 10 years after the diagnosis of radiation necrosis.

Keywords  Cerebral radiation necrosis – Brain metastasis – Germ cell tumor – WBRT – Anticoagulation

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