Perhaps the most flexible synopsis of a database is a uniform random sample of the data; such samples are widely used to speed up processing of analytic queries and data-mining tasks, enhance query optimization, and facilitate information integration. The ability to bound the maximum size of a sample can be very convenient from a system-design point of view, because the task of memory management is simplified, especially when many samples are maintained simultaneously. In this paper, we study methods for incrementally maintaining a bounded-size uniform random sample of the items in a dataset in the presence of an arbitrary sequence of insertions and deletions. For “stable” datasets whose size remains roughly constant over time, we provide a novel sampling scheme, called “random pairing” (RP), that maintains a bounded-size uniform sample by using newly inserted data items to compensate for previous deletions. The RP algorithm is the first extension of the 45-year-old reservoir sampling algorithm to handle deletions; RP reduces to the “passive” algorithm of Babcock et al. when the insertions and deletions correspond to a moving window over a data stream. Experiments show that, when dataset-size fluctuations over time are not too extreme, RP is the algorithm of choice with respect to speed and sample-size stability. For “growing” datasets, we consider algorithms for periodically resizing a bounded-size random sample upwards. We prove that any such algorithm cannot avoid accessing the base data, and provide a novel resizing algorithm that minimizes the time needed to increase the sample size. We also show how to merge uniform samples from disjoint datasets to obtain a uniform sample of the union of the datasets; the merged sample can be incrementally maintained. Our new RPMerge algorithm extends the HRMerge algorithm of Brown and Haas to effectively deal with deletions, thereby facilitating efficient parallel sampling.