Volume 6, Number 6, 547-551, DOI: 10.1007/s10024-003-5061-7

Quercetin, an Over-the-Counter Supplement, Causes Neuroblastoma-like Elevation of Plasma Homovanillic Acid

Josh Weldin, Rhona Jack, Kathryn Dugaw and Raj P. Kapur

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Abstract

A 22-month-old boy, who regularly consumed the oral dietary supplement, quercetin, was suspected erroneously of having a catecholamine-producing tumor, based on elevated serum and urine levels of the dopamine metabolite, homovanillic acid (HVA). Subsequent studies of healthy adult volunteers showed that significant elevations in plasma HVA are a consequence of quercetin ingestion.

Keywords  catecholamine - dietary supplement - homovanillic acid - neuroblastoma - quercetin - rutin

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