Peroxisome proliferator-activated receptor δ (PPARδ) regulates the expression of genes involved in lipid and carbohydrate
metabolism. To examine the association of the functional +294T/C polymorphism of
PPARD with human physical performance, the distribution of
PPARD alleles and genotypes was studied in a cohort of athletes (
N = 1256), stratified by specialization and skill level, and in controls (
N = 610). The frequency of
PPARD allele C (with a higher transcriptional activity compared to allele T) in the group of endurance-oriented athletes (
N = 898) was significantly higher than in controls (18.3% vs. 12.1%,
P < 0.0001). Moreover, in the group of endurance-oriented athletes participating in cyclic sports, the frequency of allele
C increased with growing skill level. Thus,
PPARD allele C was associated with predisposition to endurance performance.
Key words physical performance - physical qualities - fatty acid oxidation - regulatory gene -
PPARD
Original Russian Text © I.I. Ahmetov, I.V. Astratenkova, V.A. Rogozkin, 2007, published in Molekulyarnaya Biologiya, 2007,
Vol. 41, No. 5, pp. 852–857.