In recent continental philosophy of religion there has been significant attention paid to the Abrahamic doctrines of creation ex nihilo and divine omnipotence, especially by deconstructive thinkers such as Derrida, Caputo, and Keller. For these thinkers, the doctrine represents a form of agency that does violence to various forms of alterity. While broadly supportive of their fundamental philosophical and ethico-political views, especially about the primordiality of alterity, I differ from them in that I argue that creation ex nihilo articulates the very structure of the alterity they are concerned with. The essay proceeds through a reading of Derrida’s representation of the doctrine and a “deconstruction” of his view by means of a reading of Augustine and Anselm.