Through a critical analysis of Darren Aronofsky’s filmic adaptation of Hubert Selby’s Jr.’s Requiem for a Dream (2000), this article explores different relational understandings of drug using bodies and spaces of addiction. In an attempt to move away from modernist readings of addiction I look to different relational and ethical understandings of bodies and assemblages offered in the work of Gilles Deleuze and Felix Guattari. By approaching the subject of drug addiction through the film and Deleuzian–Guattarian philosophy, this article presents different insights and alternative political and ethical imaginaries of what drug bodies and spaces are and do.