Cost-sensitive learning is a key technique for addressing many real world data mining applications. Most existing research has been focused on classification problems. In this paper we propose a framework for evaluating regression models in applications with non-uniform costs and benefits across the domain of the continuous target variable. Namely, we describe two metrics for asserting the costs and benefits of the predictions of any model given a set of test cases. We illustrate the use of our metrics in the context of a specific type of applications where non-uniform costs are required: the prediction of rare extreme values of a continuous target variable. Our experiments provide clear evidence of the utility of the proposed framework for evaluating the merits of any model in this class of regression domains.