A comparative study of the adsorption activity of some medical sorbents with respect to physiologically active substances with different molecular weights has been carrried out. It is shown that Siliks (Polysorb MP) exhibits greater ability to adsorb proteins in comparison to other sorbents. In contrast, the carbon-based sorbents do not absorb proteins but have a high affinity for low-and medium-molecular-weight substances. The adsorption activity of Smecta in acid media is close to that of carbons. Due to similar chemical properties, the Siliks and Enterosgel preparations demonstrate analogous adsorption characteristics.