To illustrate the availability, effectiveness, and practical use of Open-Source tools in developing a radiology paper from its beginning to its presentation and publication. Practical use of a complete set of Open-Source applications for writing, e-mail corresponding, slide show, image retrieval, and manipulation is shown by simulating a scientific paper development. Open-Source software proved to be an inexpensive, effective, widely compatible, and user-friendly alternative to commercial toolkits in developing and deploying a scientific paper, either on paper or on slide show.