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Correlation of lung abnormalities on high-resolution CT with clinical graft-versus-host disease after allogeneic versus autologous bone marrow transplantation in children
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Original Article
Correlation of lung abnormalities on high-resolution CT with clinical graft-versus-host disease after allogeneic versus autologous
bone marrow transplantation in children
Laura Merlini1  , Irene Maria Olivia Borzani1, Mehrak Anooshiravani1, Isabelle Rochat2, Ayse Hulya Ozsahin3 and Sylviane Hanquinet1
| (1) |
Paediatric Radiology Unit, University of Geneva Children’s Hospital, Rue Willy-Donzé 6, Geneva, 1205, Switzerland |
| (2) |
Paediatric Pneumology Unit, University of Geneva Children’s Hospital, Geneva, Switzerland |
| (3) |
Paediatric Oncology Unit, University of Geneva Children’s Hospital, Geneva, Switzerland |
Received: 12 September 2007 Revised: 10 November 2007 Accepted: 1 June 2008 Published online: 4 September 2008
Abstract
Background Late-onset noninfectious pulmonary complications (LONIPCs) are life-threatening complications of bone marrow transplantation
(BMT). Several pathological patterns are described in the literature with different prognoses, and with different relationships
to graft-versus-host disease (GVHD). The role of high-resolution CT (HRCT) is not yet well established.
Objective To illustrate different patterns of LONIPCs on HRCT in allogeneic versus autologous BMT in order to investigate the correlation
with chronic GVHD (cGVHD).
Materials and methods A total of 67 HRCT scans were performed in 24 patients with noninfectious pulmonary disease at least 3 months after BMT (16
allogeneic, 8 autologous). Abnormality patterns and extension on HRCT images were correlated with the clinical outcome and
with the severity of cGVHD.
Results Of 24 patients, 9 showed LONIPCs (1 autologous, 8 allogeneic). There was a significant association between abnormalities on
HRCT and severe cGVHD ( P = 0.038), with no specific pattern. Prognosis seemed to be related to the severity of cGVHD and not to the extent of abnormalities
on HRCT.
Conclusion The significant association between abnormalities on HRCT and severe GVHD suggests that LONIPCs can be a pulmonary manifestation
of the disease. HRCT is a useful tool when combined with clinical data.
Keywords HRCT - Graft-versus-host disease - Late-onset noninfectious pulmonary complications - Bone marrow transplantation - Children
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