In this paper, we focus on the scheme for the route optimization in 6LoWPAN based MANEMO environments. If 6LoWPAN mobile routers for supporting NEMO protocol are organized by nested NEMO, this nesting of 6LoWPAN mobile router makes the extremely un-optimal route between 6LoWPAN nodes and its correspondent node. This is so, because all of the packets should be forwarded through the bi-directional tunnel which is established between 6LoWPAN mobile router and its home agent. Therefore, the more the number of nested levels, the packet route will become increasingly complex and it causes more end-to-end packet delay. This problem can be handled efficiently by applying MANEMO, which provides integration of MANET and NEMO protocols. With the application of MANEMO in 6LoWPAN, we can avoid the nested NEMO since MANET consisting of 6LoWPAN mobile routers can directly communicate with each other. In this paper, we propose an interoperable architecture between MANEMO and 6LoWPAN to solve the un-optimal route problem of the nested NEMO. With proposed scheme, we can provide the route optimization to communicate between 6LoWPAN node and correspondent node. Furthermore, we can also reduce the tunneling overhead and the end-to-end packet delay.