An innovative flowchart, called the computer access assessment, is proposed for rehabilitative professionals to perform a comprehensive assessment when determining appropriate assistive technology devices for persons with physical disabilities. According to clients special needs, we reconstruct a new computer access assessment with the following four components: (1) seating and positioning needs, (2) keyboard adaptation needs, (3) potential anatomical control site, and (4) mouse adaptation needs. Advices about special equipment needs will be provided when following this flowchart. Two cases have been studied to illustrate how to utilize computer access assessment to assist therapists in selecting appropriating devices and intervention strategies for a given client.