This paper describes a new ultrasonic scoring system based on the texture characteristics of ultrasonic liver images. This system generates an ultrasonic disease severity (UDS) score that is highly correlated with the computer morphometry (CM) score obtained from the evaluation of liver fibrosis based on the biopsy specimens. Essentially, UDS score is very similar to the CM score in the statistical presentation. Therefore, UDS score is defined mathematically referring to CM score as the scoring basis. As a result, UDS can faithfully reflect the disease progression that is determined conventionally based on the evaluation of liver fibrosis. Promising results have been obtained in experimental studies, and it will currently undergoes extensive clinical experiments.