Background
The American Joint Committee on Cancer staging system suggests that squamous-cell carcinoma of the oral cavity (OSCC) with
pN2 should be classified as stage IVA. The objective of the current study was to determine the outcome of patients with pN2
OSCC cancer according to different T status.
Methods
Between January 1996 and September 2007, a total of 270 patients with pN2 OSCC cancer were analyzed. All participants had
a follow-up of at least 2 years or were censored on the date of last follow-up. The outcome measures for this study were the
5-year rates of locoregional control, distant metastases, and survival.
Results
Five-year disease-specific survival and overall survival rates in pT1 (n = 9), pT2 (n = 98), pT3 (n = 70), and pT4 (n = 93)
patients were 78%, 66%, 49%, 35% (P = 0.0031), and 78%, 52%, 35%, 23% (P = 0.0001), respectively. Multivariable analysis revealed that pT3–4, level IV/V metastases, extracapsular spread, and poor
differentiation were independent risk factors for 5-year disease-specific survival in the entire study cohort. Specific independent
prognostic factors for 5-year disease-specific survival according to T stage were found.
Conclusions
The results of this study suggest that patients with pN2 OSCC cancer have different outcomes and prognostic factors according
to their T status. In the light of these findings, treatment strategies may be quite different.
Chun-Ta Liao and Chung-Jan Kang contributed equally to this article, and both should be considered first author.