Purpose
To asses the prevalence of fluorescein angiographic features in bilateral and multifocal Congenital Hypertrophy of the Retinal
Pigment Epithelium (CHRPE) in patients with a diagnosis of familial adenomatous polyposis.
Methods
We performed prospective angiographic and clinical examination of 49 CHPRE lesions in 15 patients.
Results
About 77.5% of CHRPE lesions were close to retinal vessels. The retinal vascular changes observed overlying and surrounding
the CHRPE were: capillary non-perfusion with an area greater than 0.5 disc diameters (41%), capillary microaneurysms (4%),
chorioretinal anastomoses (6.2%), attenuation of retinal vessels (4%), choriocapillary vessels inside the lacunae (6.2%) and
in the depigmented marginal halo (18.4%). Depigmented streaks in contact with one or both edges of the CHRPE were observed
in 79.6% of the lesions. About 9.6% of the lesions were not seen on ophthalmoscopy and could only be detected by angiography.
Conclusions
Even though the diagnosis of CHRPE is clinical, fluorescein angiography may be useful in confirming the diagnosis, as well
as detecting additional lesions not seen by means of ophthalmoscopic examination.
Keywords Fluorescein angiography - Congenital hypertrophy of the retinal pigment epithelium - Familial adenomatous polyposis - Pigmented retinal lesions