The aim of the present study was to investigate the aggregation of cardiovascular risk factors (hyperinsulinaemia, impaired
glucose tolerance, dyslipidaemia, and hypertension) in 180 (77 female, 103 male) obese and 239 control children. Blood glucose,
serum insulin and lipid levels were determined from blood samples taken after an overnight fast. Oral glucose tolerance tests
were performed and blood glucose concentrations were monitored. The body mass index, body fat (on the basis of skinfold measurements),
lean body mass and waist/hip ratio were calculated and blood pressure was measured five times in all subjects. It was shown
that only 14.4% of obese children were free from any risk factors, in contrast to 79.1% of the control children. Four risk
factors (metabolic cardiovascular syndrome) were found in 8.9% of the obese children (8.7% in males and 9.l % in females)
while none could be detected in controls. Considerable differences were also detected in the prevalence of one, two or three
risk factors between control and obese children. Patients with the metabolic cardiovascular syndrome could not be characterized
by any of the investigated anthropometric characteristics, but the duration of obesity was significantly longer in these children.
Conclusion Potential risk factors for cardiovascular diseases already tend to cluster in childhood and they are strongly associated
with obesity. Our observations suggest that the development of the metabolic cardiovascular syndrome has its origin in childhood.
Key words Childhood obesity - Hypertension - Hyperinsulinaemia - Metabolic cardiovascular syndrome - Cardiovascular risk factors
Received: 15 September 1998 / Accepted: 20 July 1999