Breakthroughs in mobile and wireless technologies have revolutionized the world in virtually every aspect. While much work has been and is being done regarding the opportunities and challenges arising from these technologies, much less exists on the unique opportunities and implications the same devices present and raise to users with special needs. Furthermore, the existing little work is normally specific to only a certain type of disability or device. While addressing a specific type of disability or mobile device has its place, it is also significant to ensure that one is operating based on a holistic perspective/framework of the entire audience of the disabled mobile device users.