Perceptual user interfaces are becoming important nowadays, because they offer a more natural interaction with the computer via speech recognition, haptics, computer vision techniques and so on. In this paper we present a visual-based interface (VBI) that analyzes users’ facial gestures and motion. This interface works in real-time and gets the images from a conventional webcam. Due to this, it has to be robust recognizing gestures in webcam standard quality images. The system automatically finds the user’s face and tracks it through time for recognizing the gestures within the face region. Then, a new information fusion procedure has been proposed to acquire data from computer vision algorithms and its results are used to carry out a robust recognition process. Finally, we show how the system is used to replace a conventional mouse for human computer interaction. We use the head’s motion for controlling the mouse’s motion and eyes winks detection to execute the mouse’s events.