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Thomas S. Deisboeck and J. Yasha Kresh
i-xix
Front matter
3-29
Part I / Introduction
Integrative Systems View of Life: Perspectives from General Systems Thinking
33-205
Part II / Complex Systems Science: The Basics
33-114
Methods and Techniques of Complex Systems Science: An Overview
115-140
Nonlinear Dynamical Systems
141-163
Biological Scaling and Physiological Time: Biomedical Applications
165-181
The Architecture of Biological Networks
183-205
Robustness in Biological Systems: A Provisional Taxonomy
Part III / Complex Adaptive Biosystems: A Multi-Scaled Approach
211-280
Section 1 / Complexity in Molecular Networks
211-226
Noise in Gene Regulatory Networks
227-245
Modeling RNA Folding
247-263
Protein Networks
265-280
Electronic Cell Environments: Combining Gene, Protein, and Metabolic Networks
283-353
Section 2 / The Cell as a Complex System
283-310
Tensegrity, Dynamic Networks, and Complex Systems Biology: Emergence in Structural and Information Networks Within Living Cells
311-332
Spatiotemporal Dynamics of Eukaryotic Gradient Sensing
333-353
Patterning by EGF Receptor: Models from Drosophila Development
357-422
Section 3 / Developmental Biology and The Cardiac System
357-374
Developmental Biology: Branching Morphogenesis
375-407
Modeling Cardiac Function
409-422
Cardiac Oscillations and Arrhythmia Analysis
425-459
Section 4 / The Immune System
425-436
How Distributed Feedbacks from Multiple Sensors Can Improve System Performance: Immunology and Multiple-Organ Regulation
437-450
Microsimulation of Inducible Reorganization in Immunity
451-459
The Complexity of the Immune System: Scaling Laws
463-533
Section 5 / The Nervous System
463-482
Neurobiology and Complex Biosystem Modeling
483-506
Modeling Spontaneous Episodic Activity in Developing Neuronal Networks
507-533
Clinical Neuro-Cybernetics: Motor Learning in Neuronal Systems
537-602
Section 6 / Cancer: A Systems Approach
537-556
Modeling Cancer as A Complex Adaptive System: Genetic Instability and Evolution
557-572
Spatial Dynamics in Cancer
573-602
Modeling Tumors as Complex Biosystems: An Agent-Based Approach
605-654
Section 7 / The Interaction of Complex Biosystems
605-629
The Complexity of Dynamic Host Networks
631-640
Physiologic Failure: Multiple Organ Dysfunction Syndrome
641-654
Aging as a Process of Complexity Loss
657-848
Part IV / Enabling Technologies
657-677
Biomedical Microfluidics and Electrokinetics
679-699
Gene Selection Strategies in Microarray Expression Data: Applications to Case-Control Studies
701-735
Application of Biomolecular Computing to Medical Science: A Biomolecular Database System for Storage, Processing, and Retrieval of Genetic Information and Material
737-761
Tissue Engineering: Multiscaled Representation of Tissue Architecture and Function
763-810
Imaging the Neural Systems for Motivated Behavior and Their Dysfunction in Neuropsychiatric Illness
811-826
A Neuromorphic System
827-836
A Biologically Inspired Approach Toward Autonomous Real-World Robots
837-848
Virtual Reality, Intraoperative Navigation, and Telepresence Surgery
849-864
Back matter
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