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Christopher G. Mathew
i-x
Front matter
1-8
The Polymerase Chain Reaction Getting Started
9-20
Direct DNA Sequencing of Complementary DNA Amplified by the Polymerase Chain Reaction
21-28
Direct Sequencing of PCR-Amplified DNA
29-37
Rapid DNA Sequence Analysis Using Fluorescent Labels
39-49
Detection of Mutations in DNA and RNA by Chemical Cleavage
51-68
Rapid Methods for Detection of Polymorphic Markers in Genomic DNA
69-76
The Analysis of Point Mutations Using Synthetic Oligonucleotide Probes
77-84
Detection of Mutations by the Amplification Refractory Mutation System (ARMS)
85-93
Automated Gene Detection Using the Oligonucleotide Ligation Assay
95-110
Detection of Point Mutations by Denaturing-Gradient Gel Electrophoresis
111-121
The Detection and Mapping of Point Mutations by RNase A Cleavage
123-132
Discontinuous Polyacrylamide Gel Electrophoresis of DNA Fragments
133-140
Extraction and Enzymatic Amplification of DNA from Paraffin-Embedded Specimens
141-146
The Use of the Polymerase Chain Reaction in the Mapping of Human Genes Using Somatic Cell Hybrids
147-157
The Southern Blot An Update
159-168
The Detection of Specific DNA Sequences by Enhanced Chemiluminescence
169-182
Pulsed-Field Gel Electrophoresis
183-196
Cloning from Gels Following Pulse-Field Gel Electrophoresis
197-221
Yeast Artificial-Chromosome (YAC) Cloning Systems
223-232
Gene Targeting for Somatic Cell Manipulation
233-254
In Situ Hybridization of Chromosomes
255-272
DNA Fingerprinting Analysis Methodology and Its Applications
273-285
DNA Fingerprinting and Forensic Medicine
287-298
The Detection of Point Mutations in Hemoglobin Defects Using Allele-Specific Oligonucleotide Probes
299-312
Detection of Gene Deletions Using Multiplex Polymerase Chain Reactions
313-325
Application of Pulsed-Field Gel Electrophoresis to Genetic Diagnosis
327-345
Molecular Diagnostics of Cancer
347-364
The Detection of Latent Virus Infection by Polymerase Chain Reaction
365-388
Mapping Inherited Diseases by Linkage Analysis
389-401
Diagnosis of Genetic Disorders with Linked DNA Markers
403-418
Software for Genetic Linkage Analysis
419-435
Creating Animal Models of Genetic Disease
437-456
Molecular Biology and Medicine Ethical Implications
457-461
Back matter
Charles R. M. Bangham
Richard A. Gibbs, Phi-Nga Nguyen and C. Thomas Caskey
Peter M. Green and Francesco Giannelli
Richard K. Wilson
R. G. H. Cotton
David R. Bentley, Roland G. Roberts and Jane Montandon
Christine J. Farr
John M. Old
Ulf Landegren
Stephen R. Dlouhy, Patricia Wheeler, James A. Trofatter, Peter J. Stambrook and Jay A. Tischfield
J. Ross Hawkins and Raymond Dalgleish
Bruce Budowle and Robert C. Allen
Colin S. Cooper and Michael R. Stratton
Cathy Abbott and Sue Povey
Michael R. Evans, Andrew L. Bertera and Dennis W. Harris
Timothy C. Richardson and Ian Durrant
Johan T. den Dunnen and Gert-Jan B. van Ommen
Peter J. Scambler and Michele Ramsay
Michele Ramsay and Carol Wicking
Julia R. Dorin and David J. Porteous
Kong H. Choo, Ruth M. Brown and Elizabeth Earle
Richard A. Wells and Swee Lay Thein
Karen M. Sullivan
Swee Lay Thein
Jeffrey S. Chamberlain, Richard A. Gibbs, Joel E. Ranier and C. Thomas Caskey
Bryan D. Young and Finbarr E. Cotter
Norman J. Maitland and Caroline Lynas
Martin Farrall
Stephen P. Bryant
Robert P. Erickson
Trefor Jenkins
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