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On Quality of Different Annotation Sources for Gene Expression Analysis
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On Quality of Different Annotation Sources for Gene Expression Analysis
Francesca Mulas22, 23 , Tomaz Curk24 , Riccardo Bellazzi22, 23 and Blaz Zupan23, 24, 25 
| (22) |
Dipartimento di Informatica e Sistemistica, University of Pavia, Italy |
| (23) |
Centro Interdipartimentale di Ingegneria dei Tessuti, Pavia, Italy |
| (24) |
Faculty of Computer and Information Science, University of Ljubljana, Slovenia |
| (25) |
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA |
Abstract
Mining of biomedical data increasingly relies on utility of knowledge repositories. In gene expression analysis, these are
often used for gene labeling with an assumption that similarly annotated genes have similar expression profiles. In the paper
we use this assumption to craft a method with which we scored six different annotation sources (e.g., Gene Ontology, PubMed, and MeSH annotations) for their utility in gene expression data analysis. Experiments show that the
sources that include manual curation perform well and, for instance, score better than automatic annotation from gene-related
PubMed abstracts. We also show that there is no clear winner, pointing at the need for methods that could successfully integrate
annotations from different sources.
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