Objective
To study the expressions of FAK and Pyk2 in human astrocytic tumors and their relationship with angiogenesis.
Methods
The S-P immunohistochemical method was used to measure the expressions of FAK, Pyk2 and VEGF proteins in 58 human brain astrocytic
tumors, and microvessel density (MVD) was detected by CD31 staining.
Results
In astrocytic tumors with I, II, III and IV grades, the positive rates of FAK were 20.00%, 26.67%, 44.44% and 50.00%, respectively,
those of Pyk2 were 40.00%, 60.00%, 77.78% and 85.00%, respectively. FAK and Pyk2 expressions, especially Pyk2, correlated
positively with VEGF expression and MVD.
Conclusion
FAK and Pyk2 plays the important role in astrocytic tumor angiogenesis through regulation to VEGF.
Key words astrocytic tumor - FAK - Pyk2 - angiogenesis
Supported by grants from the Science Research Foundation of Health Department of Hubei Province (No. JX1B019) and the Science
Research Foundation of Wuahn University (No. 301270064).