Ankle infection is a serious problem with limited published information on microbiology and associated morbidities. We describe
the laboratory findings, microbiology, and occurrence of adjacent osteomyelitis in patients with hematogenous septic ankle
arthritis. We retrospectively reviewed 30 patients with hematogenous septic arthritis of the ankle admitted over a 10-year
period. Twenty-two patients were male and eight female. The mean age was 46 years (range, 23–67 years). C-reactive protein
and erythrocyte sedimentation rate were elevated in all patients, but the peripheral white blood cell count was elevated in
only 47% of patients. Staphylococcus aureus (S. aureus) was the most common pathogen, isolated in 13 (54%) of the 24 patients
with positive cultures; four of these isolates (four of 24; 17% of positive cultures) were oxacillin-resistant. Four (17%)
of the 24 patients with positive cultures had a mycobacterial infection. We identified adjacent osteomyelitis in 30% of patients,
which was considerably associated with the presence of patient comorbidities. S. aureus is the most common pathogen in septic
ankle arthritis and empiric antibiotic therapy is recommended. Adjacent osteomyelitis may be present and a high index of suspicion
is necessary in patients with comorbidities.
Level of Evidence: Level III, diagnostic study. See the Guidelines for Authors for a complete description of levels of evidence.
Each author certifies that he has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing
arrangements, etc) that might pose a conflict of interest in connection with the submitted article.
Each author certifies that his institution has approved the human protocol for this investigation and that all investigations
were conducted in conformity with ethical principles of research.