Comparative evaluation of pharmacological effects of combined application of strophanthin with some antiadrenergic agents

P. V. Sergeev, P. A. Galenko-Yaroshevskii, S. M. Lemkina and Ya. V. Kostin

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Abstract

Pharmacological effects of strophanthin combined with the action of some antiadrenergic agents were studied on isolated frog atria and on models of acute and subacute cardiac insufficiency in rats. The studies demonstrated appreciable differences in the effects of anapriline, cordarone and tropaphen on strophanthin toxicity and on its chronoinotropic properties.

Key Words   strophanthin  -  adrenergic agents  -  combined application

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N o 5 pp. 502–505, May, 1995

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