Background
To demonstrate the efficacy of intravitreal methotrexate for treating intraocular lymphoma.
Case
A 55-year-old immunocompetent Asian man was diagnosed with intraocular lymphoma.
Observations
The patient was initially managed by intravenous administration of high-dose methotrexate. Because vitreous cells persisted
after systemic chemotherapy, methotrexate was given intravitreally thereafter. There was only self-limited corneal epitheliopathy
without major complications following intraocular injections. Ocular remission was sustained during a 21-month follow-up.
Conclusion
Intravitreal methotrexate is an effective, repeatable, and safe treatment for intraocular lymphoma. Jpn J Ophthalmol 2006;50:474–478 © Japanese Ophthalmological Society 2006
Key words chemotherapy - intraocular lymphoma - intravitreal injection - methotrexate - primary central nervous system lymphoma