We present the case of a patient with malignant transformation of a liposclerosing myxofibrous tumor. The patient had a histologically
confirmed liposclerosing myxofibrous tumor that, during a course of 22 months, spontaneously transformed into a lesion appearing
like a benign giant cell reactive lesion and subsequently into a high-grade bone sarcoma. Few such cases of spontaneous malignant
transformation of liposclerosing myxofibrous tumor have been reported. We report what we believe to be the first case documenting
spontaneous transformation of a liposclerosing myxofibrous tumor into an intermediate lesion with benign-appearing histologic
features and then into a high-grade malignant tumor.
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