DNA sequencing-by-hybridization (SBH) is a powerful potential alternative to current sequencing by electrophoresis. Different
SBH methods have been compared under the hypothesis of error-free hybridization. However both false negatives and false positive
are likely to occur in practice. Under the assumption of random independent hybridization errors, Doi and Imai [3] recently concluded that the algorithms of [15], which are asymptotically optimal in the error-free case, cannot be successfully adapted to noisy conditions. In this paper
we prove that the reported dramatic drop in performance is attributable to algorithmic artifacts, and present instead an algorithm
for sequence reconstruction under hybridization noise, which exhibits graceful degradation of performance as the error-rate
increases. As a downside, the computational cost of sequence reconstruction rises noticeably under noisy conditions.
Supported partially by the National Science Foundation under Grant DBI-9983081 and by the Kwan Im Thong Chair at the National
University of Singapore.