In this paper we evaluate the possibilities of one-sided communication, a new feature of the MPI-2 standard, on the Origin2000 for relatively short-range molecular dynamics (MD) simulations. Our algorithm is based on an asynchronous message-passing multi-cell approach using MPI as message-passing layer and the Leap-Frog/Verlet algorithm for the time integration. We compare one-sided with two different two- sided communication approaches for typical production runs (10⁵ - 10⁹ atoms) where we discuss the communication vs. computation time for in- creasing number of processes. We also show how the partitioning of the problem affects the different communication approaches. Using one-sided communication we achieved 10-70% better performance over two-sided.