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Structure-Sweetness Relationships of Aspartame Derivatives by GUHA
| Book Series | Lecture Notes in Computer Science |
| Publisher | Springer Berlin / Heidelberg |
| ISSN | 0302-9743 (Print) 1611-3349 (Online) |
| Volume | Volume 2534/2002 |
| Book | Discovery Science |
| DOI | 10.1007/3-540-36182-0 |
| Copyright | 2002 |
| ISBN | 978-3-540-00188-1 |
| DOI | 10.1007/3-540-36182-0_27 |
| Pages | 261-298 |
| Subject Collection | Computer Science |
| SpringerLink Date | Tuesday, January 01, 2002 |
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Structure-Sweetness Relationships of Aspartame Derivatives by GUHA
Jaroslava Halova7  , Premysl Zak8 , Pavel Stopka7 , Tomoaki Yuzuri9 , Yukino Abe9, Kazuhisa Sakakibara9, Hiroko Suezawa9 and Minoru Hirota9
| (7) |
Institute of Inorganic Chemistry, Academy of Sciences of The Czech Republic, CZ 250 68 Rez near Prague, Czech Republic |
| (8) |
Institute of Computer Science, Academy of Sciences of The Czech Republic, Pod vodarenskou vezi 2, CZ 182 07 Prague 8, Czech Republic |
| (9) |
Faculty of Engineering, Yokohana National University, Tokiwadai, 240 Hodogayaku, Yokohama, Japan |
Abstract
Structure-Sweetness Relationships of Aspartame derivatives have been established using fingerprint descriptors by GUHA method.
GUHA is the acronym for General Unary Hypotheses Automaton. The glucophoric hypotheses on the reasons for sweetness of aspartame
derivatives were generated. Moreover, new results on sweetness receptor site topology have been found. The results were confirmed
both by theoretical studies of other authors and chemical evidence. New knowledge obtained can be used for tailoring new aspartame
analogous as artificial sweeteners.
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