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Multiscale Modeling of Alternative Splicing Regulation
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Multiscale Modeling of Alternative Splicing Regulation
Damien Eveillard5  , Delphine Ropers6, Hidde de Jong7, Christiane Branlant6 and Alexander Bockmayr5
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LORIA, Univer itéHenriPoincaré, BP 239, 54506 Vandæuvre-lès-Nancy, France |
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Laboratoire de Maturation de ARN et Enzymologie Moléculaire, UMR 7567 CNRS-UHP, BP 239, 54506 Vandœuvre-lès-Nancy, France |
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INRIA Rhône-Alpe ,Helix Project, 655 avenue de l’Europe, 38334 Montbonnot, Saint Ismier, France |
Abstract
Alternative plicing is a key process in post-transcriptional regulation, by which several kind of mature RNA can be obtained
from the ame premessenger RNA. Using a constraint programming approach, we model the alternative plicing regulation at different
scales (single site vs. multiple sites), thus exploiting different types of available experimental data.
Part of this work wa done within the ARC INRIA “Process Calculi and Biology of Molecular Networks ”,http://contraintes.inria.fr/cpbio
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