A series of N-l,N′-(
n + 2)-bis[3-cyano(ethoxycarbonyl)-4,5-dimethylthiophen-2-yl]alkanediamides have been synthesized by acylating 4,5-dimethyl-2-amino-3-cyano(ethoxycarbonyl)thiophenes
with the corresponding dicarboxylic acid dichloroanhydrides. The results of biological tests show that the obtained bisamides
possess antiinflammatory and analgesic (non-narcotic) activity.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 6, pp. 26 – 27, June, 2005.