We tested the effects of lorazepam 0.038 mg/kg and diazepam 0.3 mg/kg on the identification of pictures of everyday objects
that were specifically modified to examine the role of different parts of the external contour. By pressing the space bar
of a computer keyboard, observers could add 1% of the total contour of each picture until it was recognized. Identification
thresholds were measured in three display conditions, depending on where along the contour the addition of contour pixels
started. In the minima condition, stimuli were initially displayed with only minima (i.e., locations along the contour where
negative curvature is strongest); all parts with negative curvature were then built up gradually from the minima and only
later on were the fragments with positive curvature shown until the contour became closed at the maxima (i.e., locations where
positive curvature is strongest). In the maxima condition, initially only the maxima were displayed, with all positive contour
built up first and then the negative curvature until the minima were reached. In the inflections condition, the points along
the contour shown first were inflections (i.e., points where curvature is locally zero because the sign of curvature changes
there) and contour was built up by adding parts of positive and negative curvature at both sides of each inflection until
the extrema (minima and maxima) were reached to close the contour of the picture. In general, picture identification was more
difficult (i.e., a larger portion of the contour was required) in the minima condition than in the maxima and the inflections
conditions. The diazepam group did not differ significantly from the placebo group, while the lorazepam group had significantly
lower performance in all three display conditions. Results are discussed in relation to previous research showing impaired
perceptual integration and impaired implicit memory under lorazepam influence.
Key words Benzodiazepine - Lorazepam - Diazepam - Picture identification - Perceptual integration - Curvature - GABAA
Received: 27 May 1997 / Final version: 1 December 1997