The CALM II study is the longest follow-up regarding dual blockade in hypertensive diabetic patients.
Lisinopril 40 mg once daily and lisinopril 20 mg in combination with candesartan 16 mg once daily did not differ significantly
in their ability to reduce systolic blood pressure in hypertensive patients with diabetes.
It is important to emphasize that the dual-blockade treatment was equally safe and was tolerated just as well as a higher
dosage of an angiotensin-converting enzyme (ACE) inhibitor and that there were similarly few incidences of side effects in
the two regimens