This paper is the first step of a multi-sensor fusion system for control of dept of desflurane anesthesia. In this study, depth of desflurane anesthesia was examined through cardiovascular-based an adaptive neuro-fuzzy system according to changing in the blood pressure and heart rate taken from the patient. The second step, in the next paper will be based on auditory evoked responses. The system designed for anesthetic agent, desflurane, because it is very popular and among the first choices of anesthesiologist for inhalation anesthesia. Intraoperative awareness resulting from inadequate anesthetic is a rare but serious complication during general anesthesia. In order to prevent possible intraoperative awareness, anesthesiologists usually apply anesthetics at level much above the minimal necessary. Anesthetic overdosing prolongs the recovery period, which may cause severe hemodynamic depression and a life-threatening scenario in critically ill patients. To increase patient safety and comfort is one of the most important potential benefits of the system. The second important aim of the study is to relase the anesthesiologist so that he or she can devote attention to other tasks that can’t yet be adequately automated. Also, to make the optimum in the area of anesthetic agent and to economize by lessening the costs of an operation are included the benefits which are coming with this system.