Aims/hypothesis
To estimate the 1-year progression rates from both IFG and IGT to diabetes in individuals identified in a pragmatic diabetes
screening programme in general practice (the ADDITION Study, Denmark [Anglo–Danish–Dutch Study of Intensive Treatment in People
with Screen-Detected Diabetes in Primary Care]).
Methods
Persons aged 40–69 years were screened for type 2 diabetes based on a high-risk, stepwise strategy. At baseline, anthropometric
measurements, blood samples and questionnaire data were collected. A total of 1,160 persons had IFG or IGT at baseline: 811
(70%) accepted re-examination after 1 year. Glucose tolerance classification was based on the 1999 WHO definition. At follow-up,
diabetes was based on one diabetic glucose value of fasting blood glucose or 2-h blood glucose.
Results
At baseline, 308 persons had IFG and 503 had IGT. The incidence of diabetes was 17.6 and 18.8 per 100 person-years in the
two groups, respectively.
Conclusions/interpretation
IFG and IGT identified in general practice during a stepwise, high-risk screening programme for type 2 diabetes have high
1-year progression rates to diabetes. Consequently, intensive follow-up and intervention strategies are recommended for these
high-risk individuals.
Keywords Blood glucose - Denmark - Follow-up study - General practice - Impaired fasting glucose - Impaired glucose tolerance - Progression rate - Screening - Type 2 diabetes