Cellular and Molecular Life Sciences
Volume 31, Number 8, 890-891, DOI: 10.1007/BF02358833

Specialia Chimica, Biochimica

In vitro metabolism of ethionine, N-acetyl-ethionine and N-acetylmethionine by rat liver microsomes

K. T. Francis and R. C. Smith

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Abstract

Rat liver microsomes deacetylated N-acetylethionine and N-acetyl-methionine to ethionine and methionine. The deacetylation of N-acetylmethionine was more rapid than the deacetylation of N-acetylethionine. Ethionine was slowly converted to ethionine sulfoxide by the microsomal preparations. N-Acetylethionine and N-acetylmethionine were not oxidized by the microsomes.
This work was supported by Public Health Service Research Grant No. HE-02615 from the National Heart Institute and by Hatch and State funds of Auburn University Agricultural Experiment Station.

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